Bakerian lecture.—The nadir of temperature, and allied problems. 1. Physical properties of liquid and solid hydrogen. 2. Separation of free hydrogen and other gases from air. 3. Electric resistance thermometry at the boiling point of hydrogen. 4. Experiments on the liquefaction of helium at the melting point of hydrogen. 5. Pyro-electricity, phosphorescence, &c [PDF]
James Dewar
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This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
wiley +1 more source
RESISTANCE AND SUSCEPTIBILITY OF CARROT ROOTS TO CROWN-GALL TUMOR FORMATION [PDF]
Richard M. Klein
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B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez+17 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
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Detection and Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Raw Seafood From the Coastal Area of Bangladesh. [PDF]
Firdous Z+7 more
europepmc +1 more source
GENETIC STUDIES ON THE MECHANISM OF ACQUIRED STREPTOMYCIN-RESISTANCE IN MICROORGANISMS
Tsutomu Watanabe
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Power and resistance: Black Americans' multifaceted perceptions of ingroup strengths and their effects on collective efficacy and resistance. [PDF]
Jeong HY, Vollhardt JR, Twali MS.
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