Results 151 to 160 of about 5,101,401 (348)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Chronic Effects of Different Resistance Training Exercise Orders on Flexibility in Elite Judo Athletes [PDF]

, 2014
Alam R. Saraiva, Víctor Machado Reis, Pablo B. Costa, Cláudio Melibeu Bentes, Gabriel Costa e Silva, Jefferson da Silva Novaes   +5 more
openalex   +1 more source

Exercise-induced hypoalgesia following proprioceptive neuromuscular facilitation and resistance training among individuals with shoulder myofascial pain: a pilot study [PDF]

, 2022
Zi-Han Xu, Nan An, Ziru Wang
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients

BMC Public Health
Purpose This study aims to investigate the impact of four exercise modes (aerobic exercise, resistance exercise, aerobic combined with resistance multimodal exercise, and stretching) on the physical performance of cancer patients.
Rui Liu, XY Gao, Li Wang
doaj   +1 more source

Does Regular Exercise without Weight Loss Reduce Insulin Resistance in Children and Adolescents?

International Journal of Endocrinology, 2013
Despite considerable efforts to tackle childhood obesity, it is recognized as one of the biggest health problems globally. Childhood obesity is a leading cause of many comorbid conditions such as metabolic syndrome and insulin resistance as well as type ...
YoonMyung Kim, HaNui Park
doaj   +1 more source

The effects of ageing and exercise on skeletal muscle structure and function [PDF]

, 2016
Musculoskeletal ageing is associated with profound morphological and functional changes that increase fall risk and disease incidence and is characterised by age-related reductions in motor unit number and atrophy of muscle fibres, particularly type II ...
Malone, John K.
core  

Effects of Resistance Exercise on Slow-Twitch Soleus Muscle of Infarcted Rats [PDF]

, 2023
L M Souza, Mariana Janini Gomes, Bruna B. Brandão, Luana Urbano Pagan, Mariana Gatto, F C Damatto, E A Rodrigues, T H D Pontes, Patrícia Aparecida Borim, Ana Angélica Henrique Fernandes, Gilson Masahiro Murata, Leonardo Antônio Mamede Zornoff, Paula S. Azevedo, Katashi Okoshi, Marina Politi Okoshi   +14 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Acute changes in passive muscle stiffness after resistance exercise: a narrative review of effects of program variables

Journal of Physical Fitness and Sports Medicine
Resistance exercise may empirically be believed to cause acute increases in passive muscle stiffness in sports and rehabilitation. An acute increase in muscle stiffness limits the joint range of motion (ROM) and may indirectly increase the risk of ...
Raki Kawama, Tatsuya Hojo, Taku Wakahara
doaj   +1 more source