Results 171 to 180 of about 5,101,401 (348)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Effects of Progressive Elastic Resistance on Kinetic Chain Exercises Performed on Different Bases of Support in Healthy Adults: A Statistical Parametric Mapping Approach

Biomechanics
Background: Shoulder exercises using elastic resistance integrated within the kinetic chain appear to modify scapular control strategies; however, a deeper understanding of these mechanisms is still needed. Objectives: We aim to compare three-dimensional
Fagner Luiz Pacheco Salles, Augusto Gil Pascoal   +1 more
doaj   +1 more source

THE EFFECT OF RESISTANCE AND ENDURANCE EXERCISE TRAINING ON MUSCLE PROTEOME EXPRESSION IN HUMAN SKELETAL MUSCLE [PDF]

, 2012
To investigate the effect of resistance and endurance training on muscle proteome expression, samples of vastus lateralis from 10 physically active young men were analysed by 2-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ...
Chang Keun Kim, Hee Jeong Son, Hyo Jeong Kim   +2 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Electromyographical Analysis of Lower Extremity Muscle Activation During Variations of the Loaded Step-Up Exercise [PDF]

, 2012
The loaded step-up exercise allows strength and conditioning practitioners to incorporate a unilateral resistance for athletes while performing extension at the hip, knee, and plantar flexion at the ankle.
Ebben, William P., Garceau, Luke, Lutsch, Brittney, Simenz, Christopher J., Suchomel, Timothy J.   +4 more
core   +1 more source

Does Tempo of Resistance Exercise Impact Training Volume? [PDF]

, 2018
Michał Wilk, Artur Gołaś, Petr Šťastný, Monika Nawrocka, Michał Krzysztofik, Adam Zając   +5 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Oxygen consumption and substrate utilization during and after resistance exercises performed with different muscle mass [PDF]

, 2016
International Journal of Exercise Science 9(1): 77-88, 2016. This study investigated the energy expenditure (EE) and substrate utilization reflected by the respiratory-exchange ratio (RER) during and after resistance exercises performed with different ...
Amorim, Paulo RS, Castinheiras Neto, Antonio G, Farinatti, Paulo   +2 more
core   +1 more source

Repeated bouts of resistance exercise with short recovery periods activates mTOR signaling, but not protein synthesis, in mouse skeletal muscle [PDF]

, 2017
Junya Takegaki, Riki Ogasawara, Yuki Tamura, Ryo Takagi, Yuki Arihara, Arata Tsutaki, Koichi Nakazato, Naokata Ishii   +7 more
openalex   +1 more source