Results 181 to 190 of about 5,101,401 (348)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Meta-Analysis of the Effect of Resistance Exercise Prescription on Glucose and Lipid Metabolism in Overweight and Obese Adults

Xiehe Yixue Zazhi
ObjectiveTo explore the effect of resistance exercise on glycolipid metabolism in over-weight or obese people, with the aim of providing reference for the clinical development of appropriate resistance exercise programs.MethodsPubMed, Cochrane Library ...
SUN Yuxin, GUO Xiaoyuan, CHEN Shi, PAN Hui, ZHU Huijuan   +4 more
doaj   +1 more source

Resistance training and the elderly : an investigation into psychological wellbeing and life satisfaction : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]

, 2005
This exploratory study examined the psychological benefits of high-intensity resistance training in an elderly age group. Participants in the sample (N=76) aged between 70-80, were randomly allocated to two groups (37 exercisers- 18 female and 19 male ...
Barker, Kevin Maxwell
core  

Impact of isometric and concentric resistance exercise on pain and fatigue in fibromyalgia

, 2021
Giovanni Berardi, Jonathon W. Senefeld, Sandra K. Hunter, Marie Hoeger Bement   +3 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Letter: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33(5):401-411, 2009) [PDF]

, 2009
Dong-Lim Kim
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Impact of Resistance Toe-Curl Exercise on Venous Blood Flow Velocity Following Foot and Ankle Immobilisation in Below-Knee Casts

Foot & Ankle Orthopaedics
Category: Trauma; Ankle Introduction/Purpose: Venous thromboembolism (VTE) is a serious complication associated with lower limb immobilisation due to casting, posing significant morbidity and mortality risks.
Steffan Rhys Evans MB ChB, Jack Samuel Perrett MB ChB, Kandasamy Sampathkumar MB ChB   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men

, 2014
Cameron J. Mitchell, Tyler A. Churchward‐Venne, Gianni Parise, Leeann M. Bellamy, Steven K. Baker, Kenneth Smith, Philip J. Atherton, Stuart M. Phillips   +7 more
openalex   +2 more sources