Molecular determinants of signal transduction in tropomyosin receptor kinases
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Resistance exercise training and blueberry extract protect against cardiac and skeletal muscle remodeling and metabolism disruptions in experimental pulmonary arterial hypertension. [PDF]
Soares LL +12 more
europepmc +1 more source
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Effects of Blood Flow Restriction Resistance Exercise Versus Traditional Resistance Exercise in Voluntary Exhaustion on Quadriceps Muscle Adaptations in Untrained Young Males: A Randomized Trial. [PDF]
Akgül MŞ +8 more
europepmc +1 more source
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Dileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated cell-based anabolism. [PDF]
Aguilera JA +11 more
europepmc +1 more source
Effect of resistance exercise on attentional bias toward food in overweight female college students: An event-related potential study. [PDF]
Wang J, Ding F, Lian S, Yu L.
europepmc +1 more source

