Results 171 to 180 of about 1,882,386 (316)

Targeted capture and cloning of Rps6 reveal redundancy in soybean resistance genes. [PDF]

BMC Plant Biol
Asselin Y, Deshaies A, Milnes L, Parthasarathy S, Santhanam P, Houghton J, Tremblay V, Labbé C, Belzile F, Witek K, Bélanger RR.   +10 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A hidden reservoir of antibiotic resistance genes: transferable plasmids in community air and wastewater. [PDF]

Front Microbiol
Luo X, Hou J, Xia D, Zhou Y, Huang N, Liu J, Zhang X, Tao X, Wang A, Li J, Qin P, Wu X, He P.   +12 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Editorial: Unraveling plant-microbe interactions: from ecology to mechanisms, volume II

Frontiers in Plant Science, 2023
Essaid Ait-Barka, Brigitte Mauch-Mani
doaj   +1 more source

Molecular Profiles and Antimicrobial Resistance Genes in Bacterial Isolates from Chronic Rhinosinusitis Patients. [PDF]

Pathogens
Osman A, Ghenea AE, Mogoanta CA, Enache I, Bucătaru A, Cioboată R, Georgescu M, Bălășoiu AT, Zlatian OM.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Global Analysis of the Co-Occurrence of Antimicrobial and Metal Resistance Genes in Bacterial Genomes From Dairy-Isolated Pathogens. [PDF]

Environ Microbiol
Almeida ACO, de Souza HCA, Fidelis J, Dos Santos AMP, Portes AB, Paim UM, Rodrigues PA, da Costa MP, Conte-Junior CA.   +8 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Unraveling the activity of phage-carrying antibiotic resistance genes in constructed wetlands. [PDF]

Front Cell Infect Microbiol
Zhao Q, Wang D, Lin H, Zhou T, Zhang J, Shang J, Cai D, Sun Y, Hu Z, Zhang J.   +9 more
europepmc   +1 more source