Results 41 to 50 of about 661,269 (265)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Driving Antibiotic Resistance Evolution of E. coli by Three Commonly Used Disinfectants Under Concentration-Increasing Stress

Microorganisms
Antimicrobial resistance (AMR) has become a major global public health challenge, and widely residual disinfectants in the environment are one of the key drivers of bacterial AMR development. This study aimed to investigate the inductive effects of three
Tianchen Wang, Yongqi Li, Yanyang Li, Mengqi Chai, Hangfei Bai, Song Jiang, Jun Xia   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Agro-physiological responses and molecular docking evaluation of some essential oils and ascorbic acid as eco-friendly inhibitors of powdery mildew in cucumber plants

Frontiers in Plant Science
IntroductionPowdery mildew is a major fungal disease affecting cucumber production, often managed using synthetic fungicides with environmental and health concerns.
Hanaa S. Omar, Ahmed Mohamed, Nehad A. El-Gammal, Reda I. Omara, Amira A. Ayad, Mohamed M. El-Mogy, Leonard L. Williams, Emad A. Abdeldaym   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Construction of a linezolid-resistant strain of methicillin-susceptible Staphylococcus aureus and its multi-omics based mechanism study

Frontiers in Cellular and Infection Microbiology
BackgroundThe emergence of linezolid−resistant methicillin−susceptible Staphylococcus aureus (MSSA) is a growing clinical threat, but the underlying mechanisms are unclear.
Wei Zhang, Linhui Huang, Yanye Tu, Feng Wang, Hong Li, Yanzi Chang, Xudong Feng, Jie Zhou   +7 more
doaj   +1 more source

In Silico Analyses of Autophagy-Related Genes in Rapeseed (Brassica napus L.) under Different Abiotic Stresses and in Various Tissues

Plants, 2020
The autophagy-related genes (ATGs) play important roles in plant growth and response to environmental stresses. Brassica napus (B. napus) is among the most important oilseed crops, but ATGs are largely unknown in this species.
Elham Mehri Eshkiki, Zahra Hajiahmadi, Amin Abedi, Mojtaba Kordrostami, Cédric Jacquard   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Chitosan reduces infection by Guignardia citricarpa in postharvest 'Valencia' oranges

Brazilian Archives of Biology and Technology, 2009
Citrus fruits are affected by the black spot disease caused by Guignardia citricarpa. Resistance induction is an alternative control measure and chitosan exhibits potential as resistance inducer. The effect of chitosan on G.
Maria Cristina Canale Rappussi, Sérgio Florentino Pascholati, Eliane Aparecida Benato, Patrícia Cia   +3 more
doaj   +1 more source