Results 81 to 90 of about 2,321,454 (339)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
InsectsEstablishing refuges is a primary strategy for managing resistance in target pests against Bt maize. The larval feeding and dispersal, and adult oviposition behaviors of Spodoptera exigua (Hübner) on Bt and non-Bt maize plants are critical factors in ...
Cheng Song +7 more
doaj +1 more source
MANAGING PEST RESISTANCE: THE POTENTIAL OF CROP ROTATIONS AND SHREDDING [PDF]
The current debate over resistance management plans mandated by the Environmental Protection Agency for transgenic crops ignores management practices that are complementary to refuge schemes.
Babcock, Bruce A., Secchi, Silvia
core +1 more source
Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance [PDF]
, 2015 The brown rat (Rattus norvegicus) is a relatively recent (
Adams, Sally +6 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Decreasing the Resistance of the Human Resources to Organizational Changes [PDF]
One of the most difficult problems faced by the management of all organizations within innovation and change processes is the resistance to change. This study, dealing with this issue, has the following main objectives: to identify the main sources of ...
Ciprian NICOLESCU, Ovidiu NICOLESCU
core
What do we (need to) know about low-susceptibility of codling moth against Cydia pomonella granulovirus (CpGV)! [PDF]
, 2006 In 2005, the first codling moth (CM) populations with a reduced susceptibility to Cydia pomonella granulovirus (CpGV) products have been observed. This phenomenon might be an indicator of an emerging resistance of CM to CpGV. This paper summarizes some
Jehle, Johannes A. +2 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Tuning thermal transport in graphene via combinations of molecular antiresonances [PDF]
, 2018 We propose a method to engineer the phonon thermal transport properties of low dimensional systems. The method relies on introducing a predetermined combination of molecular adsorbates, which give rise to antiresonances at frequencies specific to the ...
Sevim, Koray, Sevinçli, Hâldun
core +2 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source