Results 41 to 50 of about 125,774 (256)
Advances in resistant hypertension [PDF]
Annals of Translational Medicine, 2018 Resistant hypertension (RHTN) has historically been defined as high blood pressure (BP) that remains uncontrolled despite use of 3 or more antihypertensive agents from different classes, including ideally, a diuretic. In 2008, the first American Heart Association Scientific Statement on RHTN included a new category of “controlled RHTN” as high BP ...
openaire +2 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Resistant Hypertension: Detection, Evaluation, and Management
RUHS Journal of Health Sciences, 2023 Treatment resistant hypertension (RH) is an important clinical problem. Its prevalence in clinical practice ranges from 10-20%. It has been defined as failure to achieve target blood pressure (BP), usually >140/90 mmHg after taking 3 or more anti ...
Abhishek Sanadhya
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi +8 more
wiley +1 more source
A comprehensive review of an unmet public health issue: resistant hypertension
Clinical and Experimental Hypertension, 2017 Resistant hypertension is an intractable problem to patients and physicians. In recent decades, a substantial amount of basic and epidemiological studies provide us a vast number of valuable evidence and information about this once elusive disease ...
Anping Cai, Yingqing Feng, Yingling Zhou
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Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study
BMC Cardiovascular Disorders, 2009 Background It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with ...
Martín-Luengo Cándido +5 more
doaj +1 more source
Kidney Function Decline and Apparent Treatment-Resistant Hypertension in the Elderly. [PDF]
PLoS ONE, 2016 BACKGROUND:Cross-sectional studies show a strong association between chronic kidney disease and apparent treatment-resistant hypertension, but the longitudinal association of the rate of kidney function decline with the risk of resistant hypertension is ...
Jean Kaboré +6 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk +10 more
wiley +1 more source
The issue of treatment-resistant hypertension in clinical practice
Pediatria i Medycyna Rodzinna, 2014 Resistant hypertension is defined as a clinical situation characterised by a failure to achieve lower systolic and diastolic blood pressure levels below 140 mm Hg and 90 mm Hg, respectively, despite the use of the principles of lifestyle modification as ...
Andrzej Januszewicz, Aleksander Prejbisz
doaj +1 more source