Results 61 to 70 of about 56,600 (265)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Resistant Hypertension or Resistant Prescribing? [PDF]
Hypertension, 2011 See related article, pp 1008–1013 The term “resistant hypertension” (RH) evokes a myriad of clinical descriptions, nearly all of which implicitly ascribe origins of the problem to characteristics inherent within the patient or maleficent qualities of the disease itself.
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Applied SciencesThis research provides a method for a reliable fatigue life estimation at high testing frequencies. The investigations are based on the lifetime prediction method StressLifeHCF considering test frequencies of 80 and 260 Hz for normalized SAE 1045 (C45E ...
Jonas Anton Ziman +6 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Resisting Bacterial Drug Resistance [PDF]
Chemistry & Biology, 2003 In this issue of Chemistry & Biology, Wright and colleagues report an elegant method for inhibiting enzymes critical for rendering bacteria drug resistant. By using cationic peptides as inhibitors, the authors have exploited two antibacterial mechanisms, making it doubly difficult for microbial retaliation.
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Magnetochemistry, 2019 Magnetically responsive fluid based on polymers of natural rubber (NR-latex) involves a magnetic compound fluid (MCF) rubber liquid. For a wide range of engineering applications of suspensions or liquids with particles, their electrical characteristics ...
Kunio Shimada
doaj +1 more source