Results 241 to 250 of about 3,605,424 (316)

Impact of Extreme Heat on Emergency Department Admissions for Childhood and Adult Asthma: An Evaluation of Earth Observations and Heat Wave Definitions. [PDF]

Geohealth
Corpuz B, Scott E, Zaitchik BF, Zeger S, Waugh D, Balasubramanian A, Madrigano J, Koehler K, Koehl R, McCormack M.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the effectiveness of satellite image super-resolution for road quality monitoring. [PDF]

Sci Rep
Thegeya A, Mitterling T, Njoroge C, Martinez A, Iddawela Y, Bulan JAN, Durante RL, Garonita OL, Mag-Atas J.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A Tunable Catadioptric Spectrometer with Bragg-Condition-Preserving Rotation for High-Resolution Spectroscopy. [PDF]

Sensors (Basel)
Yao Z, Ren S, Wang X, Zuo D.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Early clot resolution in neonates: time to rethink duration of anticoagulation in neonatal catheter-related venous thromboembolism? [PDF]

Res Pract Thromb Haemost
Heleen van Ommen C, Bhat R.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Image Resolution's Impact on Artificial Intelligence & Human Accuracy in Full-Mouth Radiographic Analysis. [PDF]

Int Dent J
Mayer Y, Gabay E, Jazmawi S, Skvirsky Y, Mtanis T, Kivovics M, Sahar SH, Ginesin O, Giladi HZ, Gutmacher Z.   +9 more
europepmc   +1 more source