Results 191 to 200 of about 49,509 (302)

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

open access: yesAdvanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang   +6 more
wiley   +1 more source

Enabling the Fabrication of Complex Soft Iontronics Using Multi‐Material 3D Extrusion Printing

open access: yesAdvanced Science, EarlyView.
Using multi‐material 3D printing, ionic diodes and logic circuits are created using only one fabrication technique and are integrated into metamaterial scaffolds with advanced mechanical behavior, paving the way for soft devices with tunable sensitivity to mechanical strain.
Trevor J. Kalkus   +6 more
wiley   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

open access: yesAdvanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox   +9 more
wiley   +1 more source

Electron Transfer‐Tailored D‐Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning‐Empowered Intelligent Biosensing

open access: yesAdvanced Science, EarlyView.
This study pioneers a rational nanozyme design strategy guided by electron transfer mechanisms while advancing biosensing paradigms through interpretable machine learning‐enhanced signal intelligence. By transforming biosensors from passive transducers to active diagnostic systems, this work establishes a versatile framework for addressing global ...
Yuechun Li   +9 more
wiley   +1 more source

Tailoring Unusual Ferrimagnetism in Rare‐Earth Iron Garnets via Graphene Interlayers

open access: yesAdvanced Science, EarlyView.
This study presents an efficient strategy to tailor the ferrimagnetism, such as tunable orbital moments and unexpected magnetization compensated point in low‐dimensional Tm3Fe5O12 films through graphene interlayer engineering. These results pave the way for spintronics based on rare‐earth iron garnets and research in orbitronics. Abstract Ferrimagnets (
Rui Yu   +6 more
wiley   +1 more source

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