Results 71 to 80 of about 20,153 (290)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Controllability of fractional evolution systems of Sobolev type via resolvent operators
Boundary Value Problems, 2020 In this paper, we consider the nonlocal controllability of α ∈ ( 1 , 2 ) $\alpha\in (1,2)$ -order fractional evolution systems of Sobolev type in abstract spaces.
He Yang, Yanjie Zhao
doaj +1 more source
Convergence of resonances on thin branched quantum wave guides
, 2007 We prove an abstract criterion stating resolvent convergence in the case of operators acting in different Hilbert spaces. This result is then applied to the case of Laplacians on a family $X_\eps$ of branched quantum waveguides.
Aubin Th. +8 more
core +2 more sources
Parametrized Families of Resolvent Compositions
Set-Valued and Variational AnalysisAbstract This paper presents an in-depth analysis of a parametrized version of the resolvent composition, an operation that combines a set-valued operator and a linear operator. We provide new properties and examples, and show that resolvent compositions can be interpreted as parallel compositions of perturbed operators.
openaire +2 more sources
Resolving the Family Tree of Placental Mammals
PLoS Biology, 2006 Natural selection was particularly inventive in the appendage and accessory department during the evolution of placentals—an expansive category of mammals that bear live, fully developed offspring. A placental might sport webbed wings, a prehensile tail, flippers, fangs, tusks, cloven hooves, paws, claws, floppy ears, horns, or any number of other ...
openaire +4 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Asymptotics of the spectrum of inhomogeneous plate with light-weight stiff inclusions(in Ukrainian) [PDF]
Математичні Студії, 2013 The Dirichlet spectral problem for an elliptic operator of the fourthorder with singularly perturbed coefficients is considered.The problem describes the eigenmodes of a plate with finite number ofthe stiff and light-weight inclusions of an arbitrary ...
V. M. Hut, Yu. D. Golovaty
doaj