Results 131 to 140 of about 1,236 (297)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Resolvent approaches to elliptic regularity in stationary Fokker–Planck equations
Demonstratio MathematicaThis paper investigates the local regularity of solutions to stationary Fokker–Planck equations on an open set U⊂Rd $U\subset {\mathbb{R}}^{d}$ with d ≥ 2.
Lee Haesung
doaj +1 more source
Approximation of eigenvalues of some unbounded self-adjoint discrete Jacobi matrices by eigenvalues of finite submatrices [PDF]
Opuscula Mathematica, 2007 We investigate the problem of approximation of eigenvalues of some self-adjoint operator in the Hilbert space \(l^2(\mathbb{N})\) by eigenvalues of suitably chosen principal finite submatrices of an infinite Jacobi matrix that defines the operator ...
Maria Malejki
doaj
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Fuzzy Multi-dimensional Analysis and Resolution Operation [PDF]
Computer Science Journal of Moldova, 1999 In this paper a new original approach to the analysis of fuzzy multi- dimensional distributions is described. A uniform method for representing fuzzy multi-dimensional distributions by means of sectioned vectors and matrices is proposed. Sectioned matrix
Alexandr Savinov
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The resolvent and expected local times for Markov-modulated Brownian motion with phase-dependent termination rates [PDF]
, 2013 We consider a Markov-modulated Brownian motion (MMBM) with phase-dependent termination rates, i.e. while in a phase i the process terminates with a constant hazard rate ri ? 0.
Breuer, Lothar
core
Resolvent of matrix polynomials, pseudospecrta and inversion problems
, 2002 Summary: The author deals with a mathematical model for dynamical systems described by \(n\) ordinary differential equations of order \(m\) with constant coefficients. The formulae for resolvents of matrix polynomials (\(\lambda\)-matrices) and for ``derivative resolvents'' corresponding to the time differentiation as well as their differentiation with
openaire +2 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source