Results 151 to 160 of about 31,293 (331)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Hautus-Type Inequality for Abstract Fractional Cauchy Problems and Its Observability

open access: yesJournal of Mathematics
In this paper, we investigate the observability of the fractional resolvent family, and we prove two main results: the first result shows a generalization of the Hautus-type test for observable exponentially stable semigroups to the fractional resolvent ...
Li Chen-Yu
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Estimating the resolvent of elliptic second-order partial differential operators

open access: yesLe Matematiche, 1996
Sharp estimates for the resolvent of a linear elliptic second-order partial differential operator under Dirichlet homogeneous boundary conditions are derived via a symmetrization technique.
Dimitri Mugnai, Giorgio Talenti
doaj  

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