Results 201 to 210 of about 32,295 (236)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

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On Doubly Resolving Sets in Graphs

Bulletin of the Malaysian Mathematical Sciences Society, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Hermitian geometry on the resolvent set (II)

Science China Mathematics, 2021
The authors study the connection between an element belonging to a unital \(C^*\)-algebra and the properties of the metric concerning curvature, arc length, completeness and singularity. For Part I, see [Oper. Theory: Adv. Appl. 267, 167--183 (2018; Zbl 1454.47009)].
Douglas, Ronald G., Yang, Rongwei
openaire   +2 more sources

Resolving-power dominating sets

Applied Mathematics and Computation, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Stephen, Sudeep, Rajan, Bharati, Grigorious, Cyriac, William, Albert   +3 more
openaire   +3 more sources

Resolving Conflict in the Home Care Setting

Home Healthcare Nurse: The Journal for the Home Care and Hospice Professional, 2008
Conflict occurs when the needs of 2 or more people are incongruent and not being met simultaneously. Thomas defines conflict as “the process that begins when one party perceives that the other party has negatively affected, or is about to negatively affect, something he or she cares about” (cited ...
Rebecca, Askew, P Renée, Williams, Marcia, Rachel, Olivia, Martin   +3 more
openaire   +2 more sources

Hermitian Geometry on Resolvent Set

2018
For a tuple \({A} = ({A}_{1}, {A}_{2}, \ldots, {A}_{n})\) of elements in a unital Banach algebra \(\mathcal{B}\), its projective joint spectrum P(A) is the collection of \({z} \in {\mathbb{C}}^{n}\) such that \({A}(z) = {z}_{1}{A}_{1} + {z}_{2}{A}_{2} + \cdots + {z}_{n}{A}_{n}\) is not invertible.
Ronald G. Douglas, Rongwei Yang
openaire   +1 more source