Results 91 to 100 of about 8,783 (264)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
On equations containing derivative of the delta-function
Журнал Белорусского государственного университета: Математика, информатика, 2018 The expression u′′ + aδ′u, which is consisted derivative of delta-function as a coefficient, is a formal expression and doesnʼt define operator in L2(R), because a product δ′u is not defined.
Alena V. Shkadzinskaya
doaj
Resolvent Flows for Convex Functionals and p-Harmonic Maps
Analysis and Geometry in Metric Spaces, 2015 We prove the unique existence of the (non-linear) resolvent associated to a coercive proper lower semicontinuous function satisfying a weak notion of p-uniform λ-convexity on a complete metric space, and establish the existence of the minimizer of such ...
Kuwae Kazuhiro
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A primal-dual splitting algorithm for composite monotone inclusions with minimal lifting. [PDF]
Numer Algorithms, 2023 Aragón-Artacho FJ +2 more
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Existence Theorems on Solvability of Constrained Inclusion Problems and Applications
Abstract and Applied Analysis, 2018 Let X be a real locally uniformly convex reflexive Banach space with locally uniformly convex dual space X⁎. Let T:X⊇D(T)→2X⁎ be a maximal monotone operator and C:X⊇D(C)→X⁎ be bounded and continuous with D(T)⊆D(C).
Teffera M. Asfaw
doaj +1 more source