Results 101 to 110 of about 21,328 (195)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Understanding the dynamics driving obesity in socioeconomically deprived urban neighbourhoods: an expert-based systems map. [PDF]

BMC Med
Ter Ellen F, Oude Groeniger J, Stronks K, Hagenaars LL, Kamphuis CBM, Mackenbach JD, Beenackers MA, Freijer K, Coenen P, Poelman M, Oude Hengel KM, van Lenthe FJ.   +11 more
europepmc   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Building a More Resilient, Inclusive Public Health Infrastructure: Insights From Chicago's Community-Based COVID-19 Corps. [PDF]

Int J Health Plann Manage
Hebert-Beirne J, Kim S, Forst L, Kapadia G, Grant A, Velonis A, Dworkin M, Acosta M, Jay K, Ghebenei D, Thompson C, Stiehl E.   +11 more
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Exploring communication practices that promote community participation and collective action for reducing disaster risks in New Zealand. [PDF]

Disasters
Das M, Becker J, Doyle EEH.
europepmc   +1 more source

Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters

Arthritis Care &Research, EarlyView.
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US‐based skin assessments for their face validity (differentiation between involved SSc and healthy
Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L. Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin, Maureen Mayes, Shervin Assassi   +12 more
wiley   +1 more source

Community resilience to climate change and non-communicable disease vulnerability in Yaoundé, Cameroon: insights from community-based systems dynamics. [PDF]

Front Public Health
Assah F, Nfondoh B, Ngwa E, Kum TA, Elouna B, Wasnyo Y, Maria de Oliveira Morais L, Thondoo M, Wayas F, Odhiambo G, Phillips J, Abrahams N, Oni T, Lambert EV, Caiaffa WT, Garcia L, Gordon-Strachan G, Tatah L.   +17 more
europepmc   +1 more source

Diffusion‐Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients

Arthritis Care &Research, EarlyView.
Objective Maturational signal in the sacroiliac joint (SIJ) of skeletally immature youth is often misinterpreted as inflammation. Diagnostic tools that improve specificity are greatly needed. Apparent diffusion coefficient (ADC) values from diffusion‐weighted imaging (DWI), when used with standard imaging, may enhance diagnostic accuracy.
Michael L. Francavilla, Timothy G. Brandon, Dmitry Khrichenko, Rui Xiao, Nancy A. Chauvin, Asef Khwaja, Pamela F. Weiss   +6 more
wiley   +1 more source

Spatial transcriptomics elucidates localized immune responses in atherosclerotic coronary artery. [PDF]

EMBO Mol Med
Campos J, McMurray JL, Certo M, Hardikar K, Morse C, Corfield C, Weigand BM, Yang K, Shoaran M, Otto TD, Neil D, Maffia P, Mauro C.   +12 more
europepmc   +1 more source