Results 161 to 170 of about 60,505 (275)

Topological insights into breast cancer drugs: a QSPR approach using resolving topological indices. [PDF]

Front Chem
Pandeeswari E, Ravi Sankar J.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Absorption Mode Broadband 2D MS for Proteomics and Metabolomics. [PDF]

J Am Soc Mass Spectrom
van Agthoven MA, Polák M, Fiala J, Ounounou CN, Halada P, Palasser M, Briot-Dietsch A, Kádek A, Breuker K, Novák P, Afonso C, Delsuc MA.   +11 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Metric, edge-metric, mixed-metric, and fault-tolerant metric dimensions of geometric networks with potential applications. [PDF]

Sci Rep
Hayat S, Naeem R, Afzal Siddiqui HM, Riaz A, Imran M, Belay MB, Klai Z.   +6 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Optimal Design by Resolving Boolean Equations

, 2014
- The optimal design of a non-deterministic finite state machine by solving and resolving Boolean equations is shown, taking advantage of the relationships between single Boolean functions, sets of Boolean functions, Boolean equations, and their ...
Bernd Steinbach, Christian Posthoff
core  

On using clustering statistics for assessing plasmid binning tools accuracy. [PDF]

Brief Bioinform
Epain V, Mane A, Chauve C.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Ancient gene linkages and ultraconserved elements disentangle Acari interrelationships. [PDF]

iScience
Bhoi JP, Mule R, Savale N, Sharma PP, Kulkarni S.   +4 more
europepmc   +1 more source