Results 241 to 250 of about 60,505 (275)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Enhancing Chimeric Fragmentation Spectra Deconvolution Using Direct Infusion-Tandem Mass Spectrometry Across High-Resolution Mass Spectrometric Platforms. [PDF]

Rapid Commun Mass Spectrom
Ivanova A, Tang W, Simon C, Dührkop K, Böcker S, Gleixner G.   +5 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Development of a multi-targeted metabolomics platform for semi-quantification of faecal metabolites: a proof-of-concept analysis in human faeces. [PDF]

Microbiome Res Rep
Ikuta K, Kunisawa A, Dekio I, Ito A, Wang Q, Kawamura K, Yamada M, Nakamura S, Hayakawa Y, Higurashi T, Iida J, Fukusaki E, Suzuki T, Matsumoto M.   +13 more
europepmc   +1 more source

A velocity-informed framework for resolving functional stratification in rare human stem cells. [PDF]

Leukemia
Jarczak J, Ratajczak MZ, Kucia M.
europepmc   +1 more source

Bioinformatics of Combined Nuclear and Mitochondrial Phylogenomics to Define Key Nodes for the Classification of Coleoptera. [PDF]

Syst Biol
Creedy TJ, Ding Y, Gregory KM, Swaby L, Zhang F, Vogler AP.   +5 more
europepmc   +1 more source

Warpage of Injection-Moulded Thin Plates: Numerical Evaluation of Simulation Strategies and Experimental Validation. [PDF]

Polymers (Basel)
Kastelic T, Mole N, Cafuta G, Starman B, Halilovič M.   +4 more
europepmc   +1 more source

Development of core outcome sets for effectiveness trials focused on infants and children with wasting and nutritional oedema. [PDF]

BMJ Glob Health
Daniel AI, de Polnay K, McCaul M, Bendabenda J, Weise Prinzo Z, Naude CE.   +5 more
europepmc   +1 more source

A novel complex Fermatean fuzzy formalism with improved score function and aggregation operators. [PDF]

Sci Rep
Razaq A, Komal L, Alhamzi G, Baidar AW.
europepmc   +1 more source