Results 141 to 150 of about 4,264 (262)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

open access: yesAdvanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano   +11 more
wiley   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

open access: yesAdvanced Healthcare Materials, EarlyView.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen   +7 more
wiley   +1 more source

A Lightweight, 3D‐Printable, Low‐Cost, “One‐Click” Dorsal Skin Window for High‐Quality Long‐Term Multimodal Subcutaneous Tumor Imaging

open access: yesAdvanced Healthcare Materials, EarlyView.
An innovative, lightweight 3D‐printed skinfold chamber system is presented for long‐term intravital imaging. This affordable, biocompatible platform simplifies surgical implantation and allows high‐resolution, multimodal visualization of the tumor microenvironment for up to four weeks.
Iván Cortés Domínguez   +9 more
wiley   +1 more source

Resonance-free Fabry-Pérot cavity via unrestricted orbital-angular-momentum ladder-up. [PDF]

open access: yesNat Commun
Yaraghi S   +7 more
europepmc   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

open access: yesAdvanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang   +4 more
wiley   +1 more source

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

open access: yesAdvanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman   +7 more
wiley   +1 more source

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