Results 121 to 130 of about 2,602,596 (304)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Challenging (Strategic) Human Resource management Theory [PDF]

open access: yes
To fully understand the relationship between human resource management and performance in different contexts, we are in need of a synthesis between resource-based theory and new institutionalism.
Boselie, J.P.E.F., Paauwe, J.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Green innovation as a mediator of green transformational Leadership, green supply chain management on green perceived organizational support toward sustainable competitive advantage in sustainable firms in the Philippines

open access: yesDiscover Sustainability
This study examines how internal organizational factors drive green innovation (GI) and sustainable competitive advantage (SCA) through the theoretical lens of the Resource-Based View (RBV) and the Natural Resource-Based View (NRBV).
Johannes V. Gloria
doaj   +1 more source

Does Good Personnel Management Practices give Agribusiness Firms a Competitive Advantage? [PDF]

open access: yes
Agribusiness firms are often faced with the challenge of strategically managing employees to achieve a favorable position in the market (i.e. sustained competitive advantage).
Mugera, Amin W.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Firm creation in universities: a resource based view

open access: yesManagement Letters/Cuadernos de Gestión, 2008
Firm creation is used by universities not only to transfer technology to society but also to contribute to the development of the regional economy.
ALFONSO RODRÍGUEZ SANDIÁS   +3 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The Effectiveness of Based on Creating Sustainable Competitive Advantage Training and Skill Development of Insurance Representatives on Resource Based View [PDF]

open access: yesمطالعات مدیریت راهبردی, 2014
Now days, companies give their utmost effort to create competitive advantage though utilization of appropriate trainings for their sales representatives.
Ali Heidari, Mina Beigi, Mohsen Heidari
doaj  

What does it take to be good parent ? Opening the black-box of value creation in the unrealated multibusiness firm [PDF]

open access: yes
This paper develops and tests new theory about the determinants of value creation in unrelated multibusiness firms from a resource-based perspective.
Meier, Degenhard, Olivier, Gottschalg
core  

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