Results 61 to 70 of about 1,604,836 (247)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

CALCULATED EVALUATION OF MI-2 DRIVE SHAVT STRENGTH RESERVE

open access: yesНаучный вестник МГТУ ГА, 2016
A strength reserve coefficient evaluation of Mi-2 drive shaft with critical resource (4500 hours) is given in this paper. This coefficient is compared to the strength reserve coefficient evaluation of Mi-2 drive shaft with operating time of zero hours.
R. L. Semenikhin
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Training and burn care in rural India

open access: yesIndian Journal of Plastic Surgery, 2010
Burn care is a huge challenge in India, having the highest female mortality globally due to flame burns. Burns can happen anywhere, but are more common in the rural region, affecting the poor.
Shobha Chamania
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Resource Requirements in a Burn Mass Casualty Event

open access: yesEuropean Burn Journal
Burn mass casualty event occurrences are rare but will place significant burdens on any burn unit or healthcare system. Effective disaster preparedness plays a significant role in mitigating the aftermath of a burn mass casualty.
Wei Lun Wong   +4 more
doaj   +1 more source

AGRICULTURE IN THE REPUBLIC OF MOLDOVA: PRESENT AND FUTURE [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2012
Agriculture was and still is the most important source for human being and, thus, constitutes the strongest factor for economic development harmonization in any country. Agriculture is the key branch of economy in Moldova.
Simion CERTAN, Ion CERTAN
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The direct cost of care among surgical inpatients at a tertiary hospital in south west Nigeria

open access: yesThe Pan African Medical Journal, 2014
INTRODUCTION: This study was conducted to assess the direct cost of care and its determinants among surgical inpatients at university College Hospital, Ibadan.
Olayinka Stephen Ilesanmi   +1 more
doaj   +1 more source

Home - About - Disclaimer - Privacy