Results 21 to 30 of about 1,172,917 (259)

Optimized maritime emergency resource allocation under dynamic demand. [PDF]

PLoS ONE, 2017
Emergency resource is important for people evacuation and property rescue when accident occurs. The relief efforts could be promoted by a reasonable emergency resource allocation schedule in advance. As the marine environment is complicated and changeful,
Wenfen Zhang, Xinping Yan, Jiaqi Yang
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Honoring donors: medical students’ reflections on cadaveric dissection

BMC Medical Education
Background Cadaveric dissection is an essential practice for medical students to understand human anatomy and internalize professional attitudes toward death, such as empathy and respect for the deceased.
Young Gyu Kwon, Myeong Namgung, Song Hee Park, Mi Kyung Kim, Chan Woong Kim, Hyo Hyun Yoo   +5 more
doaj   +1 more source

Local healthcare resources associated with unmet healthcare needs in South Korea: a spatial analysis

Geospatial Health
Despite national initiatives to enhance healthcare accessibility, unmet healthcare needs in South Korea remain notably high, particularly in specific regions.
Sang Min Lee, Dong Woo Huh, Young Gyu Kwon   +2 more
doaj   +1 more source

Could Executive Compensation Incentive Enhance the Efficiency of Enterprise Resource Allocation? An Empirical Study from China

Discrete Dynamics in Nature and Society, 2021
Corporate executives have the decision-making power of resource allocation, and efficient resource allocation is an important measure of high-quality development of enterprises.
Xianan Yin, Hua Ming, Jing Cui, Xinzhong Bao   +3 more
doaj   +1 more source

Resource Allocation with Population Dynamics

, 2016
Many analyses of resource-allocation problems employ simplistic models of the population. Using the example of a resource-allocation problem of Marecek et al.
Epperlein, Jonathan, Marecek, Jakub
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Medical students’ perceptions of improving physician satisfaction and patient care: a text network analysis approach

BMC Medical Education
Background Physicians’ job satisfaction and their relationships with patients are critical factors in modern healthcare. Understanding medical students’ perceptions of these aspects is crucial for enhancing the quality of healthcare.
Young Gyu Kwon, Myeong Namgung, Song Hee Park, Mi Kyung Kim, Hyo Hyun Yoo, Chan Woong Kim   +5 more
doaj   +1 more source

Rethinking resource allocation in science

Ecology and Society, 2019
Many funding agencies rely on grant proposal peer review to allocate scientific funding, i.e., researchers compete for funding by submitting proposals that are reviewed and ranked by committees of their peers.
Johan Bollen, Stephen R. Carpenter, Jane Lubchenco, Marten Scheffer   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source