Results 111 to 120 of about 1,473,023 (294)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Testing Resource Description and Access (RDA) with Dublin Core
, 2011 Resource Description and Access (RDA) is a new standard for describing all types of resources. Columbia University, the University of Chicago, and the University of Illinois at Urbana-Champaign evaluated the guidelines by means of the Dublin Core element set during the U.S. National Libraries RDA Test, held from October to December 2010.
Han, Myung-Ja +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Stock market and investment : the signaling role of the market [PDF]
The author examines the role of the stock market as a signal to managers in undertaking capital expenditures. He concludes that while both managerial and market perceptions are integral, managerial perception is of greater importance.
Samuel, Cherian
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
DRIVER Technology Watch Report [PDF]
, 2008 This report is part of the Discovery Workpackage (WP4) and is the third report out of four deliverables. The objective of this report is to give an overview of the latest technical developments in the world of digital repositories, digital libraries and ...
Hochstenbach, Patrick +5 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Current Trends in Cataloguing and the Challenges of a Cataloguer in the Digital Age [PDF]
, 2013 The paper explains the cho/lenges faced by cmaloguers in this oge of Information explosion and Information Communication Technology ( ICT) and the attendant innovations and trends that are required to cope in this ne1v em•ironment.
Esse, Ugwunwa C.
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Recommendations for the representation of hierarchical objects in Europeana [PDF]
, 2013 The issue of handling hierarchical objects has been always an important topic for Europeana’s network of projects and Data Providers. The implementation of solutions in the Europeana portal has been delayed for a long time mainly due to the fact that ...
Bardi, Alessia +2 more
core +1 more source