Results 41 to 50 of about 718,540 (291)

The Influence of Land-Use Types on Forms of Potassium and Selected Soil Properties in Shashemene District, Southeastern Ethiopia

Advances in Agriculture
Understanding how land-use types influence potassium (K) forms and soil physicochemical properties is crucial for sustainable soil management. Although soils in Ethiopia are derived from K-rich parent materials, land-use change alters K dynamics ...
Cherinet Miju, Mohammed Juneydi, Araba Jemal   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Assessment of Forty-Five Bambara Groundnut (Vigna subterranea) Accessions Under Varying Environments in Kenya Using Morphological and Yield Components

International Journal of Agronomy
Understanding the agromorphological diversity of Bambara groundnut is crucial in enhancing its adaptability and productivity in Kenya, where production is localized to a few areas.
Mercy Chelangat, Bernard M. Gichimu, Phyllis W. Muturi, Josiah N. Gitari   +3 more
doaj   +1 more source

Operational assessment tool for forest carbon dynamics for the United States: a new spatially explicit approach linking the LUCAS and CBM-CFS3 models

Carbon Balance and Management, 2022
Background Quantifying the carbon balance of forested ecosystems has been the subject of intense study involving the development of numerous methodological approaches.
Benjamin M. Sleeter, Leonardo Frid, Bronwyn Rayfield, Colin Daniel, Zhiliang Zhu, David C. Marvin   +5 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Effects of Land Use Types and Soil Depths on Soil Micronutrients, Soil pH, and Organic Carbon in Southern Ethiopia

Applied and Environmental Soil Science
Soil micronutrients are vital for the enhancement of soil and crop productivity. Its deficiency can result in severe crop failure. Hence, exploring the status of soil micronutrients under different land use types and soil depths is crucial.
Kassie Getnet, Cherinet Miju, Amare Bitew, Mamaru Atinafu   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A Federated Deep Learning Empowered Resource Management Method to Optimize 5G and 6G Quality of Services (QoS) [PDF]

, 2022
Hemaid Alsulami, Suhail H. Serbaya, Emad H. Abualsauod, Asem Majed Othman, Ali Rizwan, Asadullah Jalali   +5 more
openalex   +1 more source