Results 41 to 50 of about 1,080,348 (314)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Towards a resolution of conflict in water resource allocation: A discussion based on examination of the Rakaia River debate [PDF]

, 1984
The Planning Tribunal bases its decisions on evidence presented to it by various interest groups. The study provides a critical analysis of the quality and relevance of methods which may be used in producing and presenting this evidence.
Centre for Resource Management
core  

The Influence of Land-Use Types on Forms of Potassium and Selected Soil Properties in Shashemene District, Southeastern Ethiopia

Advances in Agriculture
Understanding how land-use types influence potassium (K) forms and soil physicochemical properties is crucial for sustainable soil management. Although soils in Ethiopia are derived from K-rich parent materials, land-use change alters K dynamics ...
Cherinet Miju, Mohammed Juneydi, Araba Jemal   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessment of Forty-Five Bambara Groundnut (Vigna subterranea) Accessions Under Varying Environments in Kenya Using Morphological and Yield Components

International Journal of Agronomy
Understanding the agromorphological diversity of Bambara groundnut is crucial in enhancing its adaptability and productivity in Kenya, where production is localized to a few areas.
Mercy Chelangat, Bernard M. Gichimu, Phyllis W. Muturi, Josiah N. Gitari   +3 more
doaj   +1 more source

Ritual as resource management

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020
This paper argues that rituals are mechanisms of resource management. The argument is based on four observations: (i) over the course of hominin evolution, fitness became contingent on psychological states; (ii) these psychological states can be understood as ‘resources’, not unlike material resources such as energy, food or fuel; (iii) ritual ‘manages’
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Effects of Land Use Types and Soil Depths on Soil Micronutrients, Soil pH, and Organic Carbon in Southern Ethiopia

Applied and Environmental Soil Science
Soil micronutrients are vital for the enhancement of soil and crop productivity. Its deficiency can result in severe crop failure. Hence, exploring the status of soil micronutrients under different land use types and soil depths is crucial.
Kassie Getnet, Cherinet Miju, Amare Bitew, Mamaru Atinafu   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source