Results 131 to 140 of about 26,904,361 (346)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The global economic long-term potential of modern biomass in a climate-constrained world

Environmental Research Letters, 2014
Low-stabilization scenarios consistent with the 2 °C target project large-scale deployment of purpose-grown lignocellulosic biomass. In case a GHG price regime integrates emissions from energy conversion and from land-use/land-use change, the strong ...
David Klein, Florian Humpenöder, Nico Bauer, Jan Philipp Dietrich, Alexander Popp, Benjamin Leon Bodirsky, Markus Bonsch, Hermann Lotze-Campen   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Rediscovery of Social Reality of the City and the Village: Methodological Novations of the Study of Life Space Dynamics

Vestnik MGIMO-Universiteta, 2014
The world sociological thought pays more attention to the dynamics of urban-rural relations within the modernization of the living space. Their achievements are highlighted in the paper.
Chulpan I. Ildarhanova
doaj   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Potential Of Wave And Offshore Wind Energy In Around The Coastline Of Malaysia That.Face The South China Sea. [PDF]

, 2003
The world wide estimated wave energy resource is more than 2 TW. Offshore wind speeds are generally higher than wind speeds over land, hence higher available energy resource.
Zainal, Z. A., Narayana, P. A, Aswatha, Seetharamu, K. N., Chiang, E.P.   +3 more
core   +1 more source

A Quantitative Particle-Based Approach for the Geometallurgical Assessment of Tailings Deposits

Earth Science, Systems and Society
Tailings generated during ore processing may host significant residual contents of valuable commodities, including critical metals. The particle properties of the tailings, such as mineralogy, particle size, and the surface liberation of ore minerals ...
Rosie Blannin, Max Frenzel, Raimon Tolosana-Delgado, Kai Bachmann, Alexandra Gomez Escobar, Lucas Pereira, Jens Gutzmer   +6 more
doaj   +1 more source

Assessment of geothermal resource potential in Changbaishan utilizing high-precision gravity-based man-machine interactive inversion technology. [PDF]

Front Big Data, 2023
Xu ZH, Jiang JY, Gu GW, Sun ZJ, Jiao XK, Niu XG, Yu Q.   +6 more
europepmc   +1 more source