Results 81 to 90 of about 48,799 (251)

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

open access: yesAdvanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao   +18 more
wiley   +1 more source

Spare capacity modelling and its applications in survivable iP-over-optical networks [PDF]

open access: yes, 2006
As the interest in IP-over-optical networks are becoming the preferred core network architecture, survivability has emerged as a major concern for network service providers; a result of the potentially huge traffic volumes that will be supported by ...
Al-Barrak, S., Harle, D.A.
core   +1 more source

Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Targeted FABP5 co‐delivery nanoparticles amplify RFA‐induced ferroptosis and intratumoral immune rewiring via STING/TBK1 pathway activation in HCC. The pH‐responsive lipid nanoshell was integrated with cyclic RGD peptide (cRGD) and red blood cell membrane (RBCM), and encapsulated with superparamagnetic iron oxide (SPIO) and sgFABP5 to construct FS@RBCM/
Bufu Tang   +16 more
wiley   +1 more source

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis

open access: yesAdvanced Science, EarlyView.
The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu   +25 more
wiley   +1 more source

Resource Reservation Protocol (RSVP) Extensions for Path-Triggered RSVP Receiver Proxy [PDF]

open access: yes, 2010
RSVP signaling can be used to make end-to-end resource reservations in an IP network in order to guarantee the QoS required by certain flows. With conventional RSVP, both the data sender and receiver of a given flow take part in RSVP signaling. Yet, there are many use cases where resource reservation is required, but the receiver, the sender, or both ...
Le Faucheur, F   +5 more
openaire   +2 more sources

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

open access: yesAdvanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo   +8 more
wiley   +1 more source

GRIDCC: Real-time workflow system [PDF]

open access: yes, 2007
The Grid is a concept which allows the sharing of resources between distributed communities, allowing each to progress towards potentially different goals.
Akram, A   +7 more
core  

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