Results 131 to 140 of about 612,199 (302)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Resource selection of a nomadic ungulate in a dynamic landscape. [PDF]

PLoS One, 2021
Stratmann TSM, Dejid N, Calabrese JM, Fagan WF, Fleming CH, Olson KA, Mueller T.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effects of Bait on Male White-Tailed Deer Resource Selection. [PDF]

Animals (Basel), 2021
Johnson JT, Chandler RB, Conner LM, Cherry MJ, Killmaster CH, Johannsen KL, Miller KV.   +6 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Modeling the occurrence of the Yellow Rail (Coturnicops noveboracensis) in the context of ongoing resource development in the oil sands region of Alberta

Avian Conservation and Ecology, 2020
Yellow Rails (Coturnicops noveboracensis) are among the most secretive bird species in North America. They are poorly sampled by common survey protocols, and as a result their occurrence across much of their range is uncertain.
Richard W. Hedley, Logan J. T. McLeod, Daniel A. Yip, Dan Farr, Paul Knaga, Kiel L. Drake, Erin Bayne   +6 more
doaj  

TARS: A Novel Mechanism for Truly Autonomous Resource Selection in LTE-V2V Mode 4. [PDF]

Sensors (Basel), 2021
Khan IA, Shah SAA, Akhunzada A, Gani A, Rodrigues JJPC.   +4 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Location-Aware Resource Discovery and QoR-Driven Resource Selection for Hybrid Web Environments. [PDF]

Sensors (Basel), 2021
Kallab L, Chbeir R, Mrissa M.
europepmc   +1 more source

Reverse combinatorial auction-based protocols for resource selection in grids

, 2009
Grid computing provides an extremely promising distributed paradigm for executing large-scale resource-intensive applications. Given a distributed pool of resources, a grid user is faced with the problem of selecting an optimal set of resources.
Radhanikanth, G. V. R., Narahari, Y.
core   +1 more source