Results 81 to 90 of about 2,284,877 (259)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Mode Selection, Resource Allocation and Power Control for D2D-Enabled Two-Tier Cellular Network

open access: yes, 2016
This paper proposes a centralized decision making framework at the macro base station (MBS) for device to device (D2D) communication underlaying a two-tier cellular network.
Durrani, Salman   +3 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Partial Niche Partitioning in Three Sympatric Gull Species Through Foraging Areas and Habitat Selection

open access: yesEcology and Evolution
Anthropogenic habitat change is having a detrimental impact on biodiversity worldwide, altering the foraging behaviour and population dynamics of many species.
Nina J. O'Hanlon   +11 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Model of grid resource selection based on the trust moment

open access: yesTongxin xuebao, 2012
The trust torque was defined as the product of trust gravitation and trust radius and the grid resource selection model based on trust torque was proposed.The grid resources are divided into many trusted resource domains according to different types and ...
Yu-ling LIU   +3 more
doaj  

Exploiting Interference Alignment in Multi-Cell Cooperative OFDMA Resource Allocation

open access: yes, 2011
This paper studies interference alignment (IA) based multi-cell cooperative resource allocation for the downlink OFDMA with universal frequency reuse. Unlike the traditional scheme that treats subcarriers as separate dimensions for resource allocation ...
Da, Bin, Zhang, Rui
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Optimal Mode Selection in D2D-Enabled Multi-Base Station Systems

open access: yes, 2016
In this paper, we consider device-to-device (D2D) communication underlaying uplink cellular networks with multiple base stations (BSs), where each user can switch between traditional cellular mode (through BS) and D2D mode (by connecting proximity user),
Liu, Yuan
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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