Results 101 to 110 of about 1,780,875 (305)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Soil SystemsTropical acidic soils exhibit inherently low fertility and reduced microbial activity, driven by low pH and accelerated organic matter mineralization, phosphorus (P) fixation, and aluminum (Al3+) and iron (Fe3+) toxicity.
Isaac Asirifi +7 more
doaj +1 more source
Integrated water resource systems: Theory and policy implications. [PDF]
Water resource management / Water policy / Irrigation efficiency / Water demand / Leaching / Water use efficiency / Water supply / Evapotranspiration / Models / Water ...
Keller, Andrew. +2 more
core
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Zooplankton Indicators of Ecological Functioning Along an Urbanisation Gradient
DiversityZooplankton is an essential functional component of the aquatic food web, reflecting, through its structure and biomass, the impact of anthropogenic pressures on ecosystems.
Larisa I. Florescu +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
INCREASES IN COSTS AND RETURNS DUE TO INTENSIFYING RANGE FORAGE PRODUCTION SURVEYS: AN INFORMATION ECONOMIC ANALYSIS [PDF]
The U.S. Congress and courts have directed federal natural resource agencies to use better information for management decisions than they have used in the past.
Driscoll, Richard S. +2 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Performance of Smallholder Agriculture Under Limited Mechanization and the Fast Track Land Reform Program in Zimbabwe [PDF]
agricultural mechanization, fast track land reform, agricultural development, Stochastic Frontier model, technical efficiency, agribusiness management, Agricultural and Food Policy, Community/Rural/Urban Development, International Development, Land ...
Chisango, Future Fortune T. +1 more
core +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source