Results 51 to 60 of about 1,780,875 (305)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Journal of Integrative Agriculture, 2016 Planting at an optimum density and supplying adequate nitrogen (N) to achieve higher yields is a common practice in crop production, especially for maize (Zea mays L.); however, excessive N fertilizer supply in maize production results in reduced N use ...
De-yang SHI +5 more
doaj +1 more source
The Indian Journal of Agricultural Sciences, 2020 Field studies were conducted during rabi season of 2015–16 to 2017–18 at research farm of Advanced Centre for Rainfed Agriculture, SKUAST-Jammu to study the effect of foliar application of nutrients on crop performance, economics, resource use ...
VIKAS ABROL +9 more
doaj +1 more source
Frontiers in Environmental Science, 2022 Improving resource use efficiency is an effective way to accelerate the realization of “carbon emission peak” and “carbon neutrality.” To perform a thorough analysis of the temporal and spatial variations in Zhejiang’s agricultural sustainable ...
Linlin Fu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Comparison of resource use for farmed shrimp in Ecuador, India, Indonesia, Thailand, and Vietnam
Aquaculture, Fish and Fisheries, 2021 The purpose of this study was to assess the amounts of land, water, energy in fuels, and wild fish for fishmeal and fish oil in feeds required per tonne of harvested, farmed shrimp in five countries producing most of the shrimp destined for the ...
Claude E. Boyd +2 more
doaj +1 more source
Quantum teleportation using non-orthogonal entangled channels
, 2010 We study quantum teleportation with the resource of non-orthogonal qubit states. We first extend the standard teleportation protocol to the case of such states. We investigate how the loss of teleportation fidelity resulting for the use of non-orthogonal
A K Pan +11 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source