Results 81 to 90 of about 1,780,875 (305)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Resource Use Efficiency of Millet/Cowpea Intercropping in Niger State, Nigeria [PDF]

open access: yes
The study examined the profitability and resources-use efficiency of millet/cowpea mixed farmers production in Niger state Nigeria. The primary data for the study was obtained using structured questionnaire administered to 80 randomly sampled farmers in ...
Adiele, M.A.   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Profitability, Resource Use Efficiency and Marketing of Potato in East Siang Districts of Arunachal Pradesh, India

open access: yesInternational Journal of Bio-Resource and Stress Management, 2022
The present study was undertaken with a sample size of 90 potato growers of East Siang district of Arunachal Pradesh State, India through stratified random sampling during 2019–20. The cost of cultivation was estimated based on cost concept.
Lakshmi Dhar Hatai
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

FARMERS RESOURCE – USE AND TECHNICAL EFFICIENCY IN COWPEA PRODUCTION IN NIGERIA [PDF]

open access: yes
In Nigeria, the use of stochastic frontier to estimate farm level efficiency effects is still at the rudimentary level and is beginning to build up. Few studies have been undertaken but there is dearth need for more empirical studies on this important ...
A.T. Akanbi   +2 more
core  

High temperature control in mediterranean greenhouse production: The constraints and the options [PDF]

open access: yes, 2011
In the open field, the environment is a critical determinant of crop yield and produce quality and it affects the geographical distribution of most crop species.
Pascale, S., de, Stanghellini, C.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Energy Efficiency Resource Standards: Economics and Policy [PDF]

open access: yes
Twenty states in the United States have adopted energy efficiency resource standards (EERS) that specify absolute or per¬centage reductions in energy use relative to business as usual.
Brennan, Timothy J., Palmer, Karen
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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