Results 91 to 100 of about 277,827 (266)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Rhizosphere Bacillus proteolyticus Strain Enhances the Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. Growth in Roots and Soil Nutrient Status While Enriching the Plant-Beneficial Bacteria in Rhizosphere

Biology
This study aimed to investigate the promoting mechanisms of Bacillus proteolyticus (B. proteolyticus) on Eleutherococcus senticosus (Rupr. and Maxim.) Maxim. (therm E. senticosus) root development. Using therm E. senticosus seeds as experimental material,
Ye Zhang, Xiaoqing Tang, Jiaying Qi, Weixue Zhong, Xiaohui Li, Zhonghua Tang, Ying Liu, Dewen Li   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Recent Advances in the Application of VO₂ for Electrochemical Energy Storage

Nanomaterials
Energy storage technology is crucial for addressing the intermittency of renewable energy sources and plays a key role in power systems and electronic devices.
Yuxin He, Xinyu Gao, Jiaming Liu, Junxin Zhou, Jiayu Wang, Dan Li, Sha Zhao, Wei Feng   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Comparisons of Soil C–N Pools and Microbial Communities Among Saline–Alkali, Straw-Returning, and Conventional Farmlands in the Ningxia Yellow River Irrigation District, China

Agronomy
The Ningxia Yellow River Irrigation District in China has long been influenced by flood irrigation and intensive fertilizer input under its particular geological and climatic constraints, and this region is characterized by low soil organic matter, poor ...
Huirong Zhang, Tianyi Chen, Chuhan Yang, Xuantong Zheng, Man Wang, Taotao Zhan, Xuxin Ding, Ping Wang, Qingqian Yao, Fang Wang, Jinpeng Liu   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Bifunctional TiO₂@AgNP Superstructures as a SERS-Sensing Platform for Identifying Flavonoids in Chinese Herbal Medicine

Biosensors
Acanthopanax senticosus is an essential medicinal herb in traditional Chinese medicine, with its pharmacological properties largely attributed to bioactive flavonoids.
Yulin Li, Junbo Li, Haisu Wang, Shaorui Qi, Zhehao Zhang, Yaqiu Wang, Ying Wang, Wei Ji   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source