Results 141 to 150 of about 15,653,492 (359)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Resources and Resourcefulness [PDF]
, 2015 Recent studies in the DRC tend to focus on human rights abuses or on the status of women, however few investigations examine the link between mining and sexual violence. There is a dearth of research specifically into the gender dimensions of artisanal and small-scale mining (ASM) as a means ...
openaire +2 more sources
The State of General Operating Support 2011 [PDF]
, 2012 In 2011, 1,121 American grantmakers reported $5.9 billion in general operating support, a substantial increase (83 percent) over average core support from 2008-2010.
Kevin Laskowski, Niki Jagpal
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Summer Snapshot: Exploring the Impact of Higher Achievement's Year-Round Out-of-School-Time Program on Summer Learning [PDF]
, 2011 Assesses the impact of a multiyear, intensive, academically focused OST program for motivated but underserved middle school students on test scores, summer program participation, and summer learning loss.
Amy J. A. Arbreton +3 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Analysis of Georgia's Unemployment Insurance Trust Fund Reserves [PDF]
, 2006 This report analyses several aspects of Georgia's Unemployment Insurance Trust Fund, including the structure and the appropriate target level for the Trust Fund balance for the state of Georgia.
Edward Sennoga
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source