Results 201 to 210 of about 12,337,601 (330)

Advance care planning in Japan: Gaps between policy, ethical understanding, and its translation into clinical practice. [PDF]

Palliat Care Soc Pract
Ito K, Tsuda S, Shimizu K, Iwakiri R, Nakajima G, Hida A, Furuta K.   +6 more
europepmc   +1 more source

The need to respect nature and its limits challenges society and conservation science

Proceedings of the National Academy of Sciences of the United States of America, 2016
Jean-Louis Martin, V. Maris, D. Simberloff   +2 more
semanticscholar   +1 more source

A Respect for Facts [PDF]

Geoffrey H. Moore
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Benchmarking "Adequate Professionalism" During Undergraduate Medical Education: An Exploratory Survey Study. [PDF]

J Med Educ Curric Dev
Goodwin AM, Oliver SW.
europepmc   +1 more source

Prudence with Respect to Ambiguity

, 2017
A. Baillon
semanticscholar   +1 more source

Urban planning with respect to environmental quality and human well-being.

Environmental Pollution, 2016
T. Panagopoulos, José Antonio González Duque, Maria Bostenaru Dan   +2 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dynamical complexity of a three species food chain model incorporating delays and toxic habitat. [PDF]

Sci Rep
Thommandru DR, Sarkar A, Mondal B, Kundu S.   +3 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source