Results 221 to 230 of about 19,341,281 (268)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Pressure and Temperature Dependence of Optical Resonance Wavelength (ORW) of Large-Element Surface-Micromachined Optical Ultrasound Transducers (SMOUTs). [PDF]

Sensors (Basel)
Upadhyay K, Fang C, Yan Z, Li X, Zou J.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Deep learning-based lung volume estimation with dynamic chest radiography. [PDF]

J Appl Clin Med Phys
Ishihara N, Tanaka R, Kikuno H, Ohkura N, Matsumoto I.   +4 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption. [PDF]

Gut Microbes
Chen Y, Du H, Zhou W, Qin M, Li M, Jin Y, Xu Y, Ma C, Xia J, Mo Y, Chen N, Huang H, Li H, Xie Z, Wang P, Hong Y.   +15 more
europepmc   +1 more source

Systemic Activation of the Antioxidant System by Root Priming With Non-Pathogenic Fusarium oxysporum in Flax Infected With Pathogenic Fusarium oxysporum. [PDF]

Environ Microbiol Rep
Burgberger M, Mierziak J, Wojtasik W.
europepmc   +1 more source

Detection, Discrimination, and Localization of Rotor Winding Faults in Doubly Fed Induction Generators Using a Three-Layer ZSC-CASI-CADI Framework. [PDF]

Sensors (Basel)
Aziz MS, Zhang J, Ruzimov S, Huang X, Ahmad A.   +4 more
europepmc   +1 more source