Results 301 to 310 of about 3,346,625 (362)

Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective. [PDF]

Int J Mol Sci
Chu S, Woodfin S, Bayliss E, Smith M, Fulp A, Mirabelli E, Moore W.   +6 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Beyond energy: Mitochondrial control of platelet lifecycle through redox, calcium, and dynamics. [PDF]

Redox Biol
Wang X, Liao R, Huang Q, Li J, Li X, Gan X, Wang Y, Zhao C, Mei Q, Chen J, Wu A, Zhou X, Wu J.   +12 more
europepmc   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Inhibition of NOX4 attenuates muscle damage and mitochondrial dysfunction in inflammatory myopathy. [PDF]

Arthritis Res Ther
Kang HR, Kim JY, Kim SU, Kwon HS, Ban SY, Kim MG, Moon JH, Lee EY.   +7 more
europepmc   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Energy Metabolism Under Stress: Late-Stage Leigh Syndrome Reveals Profound Cardiometabolic Perturbations in Ndufs4 KO Mice. [PDF]

J Inherit Metab Dis
Terburgh K, Sweeney N, Louw R.
europepmc   +1 more source

Deficiency of Microglial-Derived Spp1 Exacerbates Age-Related Memory Decline by Impairing Mitochondrial Complex I Function. [PDF]

Aging Cell
Wang M, Chang Y, He A, Yang J, Li A, Wang H, Lim KL, Guo X, Zhang C, Lu L.   +9 more
europepmc   +1 more source

Mitochondrial Base Editing of the m.8993T>G Mutation Restores Bioenergetics and Neural Differentiation in Patient iPSCs. [PDF]

Genes (Basel)
Yin L, Yin A, Jones M.
europepmc   +1 more source

Disordered Coordination of Deglutition and Respiration in Chronic Obstruction Pulmonary Disease

, 2014
Jayma L Stroud
openalex   +1 more source