Results 141 to 150 of about 11,837,947 (410)

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao, Samuel J. Teener, Ian F. Webber‐Davis, Lili Zhao, Eva L. Feldman, Stephen A. Goutman   +8 more
wiley   +1 more source

Nasal lysine aspirin challenge in the diagnosis of aspirin - exacerbated respiratory disease [PDF]

, 2013
Background Aspirin-exacerbated respiratory disease is under-diagnosed and therefore effective and inexpensive therapy with aspirin desensitization is rarely performed.
Darby, Y, Gane, S, Larco, J, Miller, B, Mirakian, R, Sannah, AA, Scadding, G   +6 more
core   +1 more source

Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study

Trials, 2019
Background Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease.
Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu, Jian Wang   +8 more
doaj   +1 more source

A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across three cohorts, we built an accelerated failure time model to predict the risk of future severe (≥ 10%) weight loss using five single‐timepoint ...
David G. Lester, Kevin Talbot, Martin R. Turner, Alexander G. Thompson, the Pooled Resource Open‐Access ALS Clinical Trials Consortium   +4 more
wiley   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P., Portelli, Michael A., Sayers, Ian   +2 more
core  

Diarrhoea, acute respiratory infection, and fever among children in the Democratic Republic of Congo [PDF]

, 2009
Several years of war have created a humanitarian crisis in the Democratic Republic of Congo (DRC) with extensive disruption of civil society, the economy and provision of basic services including health care.
Ahiadeke, Boerma, Dunyo, Einterz, Ezzati, Ezzati, Fahrmeir, Francesco P. Cappuccio, Gakidou, Guerrant, Jacques B. Emina, Kandala, Kandala, Kandala, Kandala, Kazembe, Lopez, Martin-Prével, Martorell, Ngianga-Bakwin Kandala, Parashar, Paul Denis K. Nzita, Pongou, Roberts, Smith, Snyder, UNDP, Vaahtera, Waters, Woldemicael, Yoannes   +30 more
core   +1 more source

Global, regional, and national burden of chronic obstructive pulmonary disease and its attributable risk factors from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021

Respiratory Research
Background Chronic obstructive pulmonary disease (COPD) continues to be a significant issue, leading to premature death or reduced quality of life. It’s important to assess the current burden of COPD and its risk factors on a geographical basis to guide ...
Zhufeng Wang, Junfeng Lin, Lina Liang, Feifei Huang, Xiaoyin Yao, Kang Peng, Yi Gao, Jinping Zheng   +7 more
doaj   +1 more source

Global Impact of Respiratory Disease

Chest, 2022
S. Levine, D. Marciniuk
semanticscholar   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Whole-Genome Sequencing and Concordance Between Antimicrobial Susceptibility Genotypes and Phenotypes of Bacterial Isolates Associated with Bovine Respiratory Disease. [PDF]

, 2017
Extended laboratory culture and antimicrobial susceptibility testing timelines hinder rapid species identification and susceptibility profiling of bacterial pathogens associated with bovine respiratory disease, the most prevalent cause of cattle ...
Abdo, Zaid, Aly, Sharif S, Belk, Keith, Blanchard, Patricia C, Davis, Jessica H, Lehenbauer, Terry W, Miller, Michael R, Morley, Paul, Noyes, Noelle, O'Rourke, Sean M, Owen, Joseph R, Prince, Daniel J, Van Eenennaam, Alison L, Young, Amy E   +13 more
core   +2 more sources