Results 301 to 310 of about 2,136,278 (361)

Dupilumab treatment has no effect on the nasal microbiome in patients with NSAID-exacerbated respiratory disease: a longitudinal pilot study. [PDF]

Front Immunol
Bartosik T, Pjevac P, Séneca J, Morgenstern C, Arnoldner T, Gangl K, Sinz C, Campion NJ, Tu A, Stanek V, Bangert C, Schneider S, Eckl-Dorna J.   +12 more
europepmc   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

Advanced Science, EarlyView.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo, Yuting Luo, Sicheng Chen, Tiantian Yang, Bixia Liu, Xiting Liao, Xiaoke Zheng, Tian Tian, Jinxu Liu, Qinru Zhan, Xiaohua Situ, Zhongpeng Xie, Yanxia Wang, Zhe‐Sheng Chen, Honglei Chen, Zheng Yang, Zunfu Ke   +16 more
wiley   +1 more source

Lipid-lowering drug targets associated with risk of respiratory disease: a Mendelian randomization study. [PDF]

BMC Pulm Med
Gong Z, Wu D, Ku Y, Zou C, Qiu L, Hao X, Liu L.   +6 more
europepmc   +1 more source

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source

Detection of Respiratory Disease Based on Surface-Enhanced Raman Scattering and Multivariate Analysis of Human Serum. [PDF]

Diagnostics (Basel)
Khristoforova Y, Bratchenko L, Kupaev V, Senyushkin D, Skuratova M, Wang S, Lebedev P, Bratchenko I.   +7 more
europepmc   +1 more source

Development of a Multiplex Real-Time PCR Assay for the Detection of Eight Pathogens Associated with Bovine Respiratory Disease Complex from Clinical Samples. [PDF]

Microorganisms
Hao F, Tao C, Xiao R, Huang Y, Yuan W, Wang Z, Jia H.   +6 more
europepmc   +1 more source

Nasal pathobiont abundance is a moderate feedlot-dependent indicator of bovine respiratory disease in beef cattle. [PDF]

Anim Microbiome
Centeno-Delphia RE, Glidden N, Long E, Ellis A, Hoffman S, Mosier K, Ulloa N, Cheng JJ, Davidson JL, Mohan S, Kamel M, Szasz JI, Schoonmaker J, Koziol J, Boerman JP, Ault A, Verma MS, Johnson TA.   +17 more
europepmc   +1 more source