Results 331 to 340 of about 12,340,249 (385)

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Adenovector 26 Encoded RSV Prefusion F Protein (Ad26.RSV.preF) Does Not Predispose to Enhanced Respiratory Disease in Preclinical Rodent Models. [PDF]

Vaccines (Basel)
Bolder R, King SBS, Zahn RC, van der Fits L.   +3 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Bridging Gaps in Occupational Respiratory Disease Management: A Comparative Survey of Pulmonologists and Occupational Physicians in Italy. [PDF]

Clin Pract
Tortorella A, Marinelli A, De Maria L, Dragonieri S, Del Vecchio G, Quaranta VN, Portacci A, Carpagnano GE, Vimercati L.   +8 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle. [PDF]

Front Vet Sci
Herrick AL, Kiser JN, White SN, Neibergs HL.   +3 more
europepmc   +1 more source

Understanding metaphylaxis practices for cattle at uncertain risk for bovine respiratory disease across U.S. feedlots: a survey of veterinarians and feedlot managers. [PDF]

Transl Anim Sci
Horton V, Hanthorn CJ, Thackrah A, Renter D, Cernicchiaro N.   +4 more
europepmc   +1 more source

Association of ABO blood group with respiratory diseases hospitalisation and severe outcomes: a retrospective cohort study in blood donors

Shu Su, Lingxia Guo, Ting Ma, Yang Sun, Aowei Song, Wenhua Wang, Xiaoyu Gu, Wenjie Wu, Xinxin Xie, Liqin Wang, Leilei Zhang, Shiyi He, Lei Zhang, Jiangcun Yang   +13 more
openalex   +1 more source

No Longer a Great Gulf Fixed? Introduction to an <i>AJRCCM</i> Special Section on Respiratory Disease across the Developmental Spectrum. [PDF]

Am J Respir Crit Care Med
Bush A.
europepmc   +1 more source