Results 231 to 240 of about 1,251,104 (291)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Depemokimab and the twice-yearly regimen: pharmacological implications and therapeutic positioning in severe eosinophilic respiratory diseases. [PDF]

Front Immunol
Marra AM, Bizzi E, Gidaro A, Bini F, Rotunno S, Modica S, Greco E, Mauro A, Mascolo R, Tombetti E, Lazzeroni M, Paciullo F, Abatianni G, Gagliardi C, Damanti S, Rovere Querini P.   +15 more
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Single-Cell Mapping of Genetic Risk Across Ten Respiratory Diseases. [PDF]

Biology (Basel)
Zhou M, Xue C.
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Interleukin-37 in respiratory diseases: molecular mechanisms and immune modulation. [PDF]

Front Immunol
Cao J, He K, Chen Z, Xu H, Wei J, Yan X, Song B.   +6 more
europepmc   +1 more source

Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases. [PDF]

Cell Mol Life Sci
Agrawal S, Oyamada H, Korvink NS, Zhou S, de Melo Bento CA, Rahmatpanah F, Subramanian VS, Agrawal A.   +7 more
europepmc   +1 more source

The classic Chinese medicine weijing decoction as a complementary intervention for respiratory diseases: A systematic review and meta-analysis. [PDF]

J Ayurveda Integr Med
Li L, Zheng Y, Li J, Zhao L, Lin X, Zhang H, Chen H, Yan P.   +7 more
europepmc   +1 more source

Mapping the mortality niche of chronic lower respiratory diseases complicated by respiratory failure: a multiscale spatial analysis of environmental and social drivers. [PDF]

Front Public Health
Miao D, Li J, Bai X, Song Z, Gan J, Hu X, Chen W, Tian Y, Ye X, Zheng J.   +9 more
europepmc   +1 more source

Publisher Correction: Inhaled biologics for respiratory diseases: clinical potential and emerging technologies. [PDF]

Drug Deliv Transl Res
Shaibie NA, Mohammad Faizal NDF, Buang F, Srichana T, Mohd Amin MCI.   +4 more
europepmc   +1 more source