Results 81 to 90 of about 1,672,166 (295)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome

Brazilian Journal of Medical and Biological Research, 2005
Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns.
A.C.W. Benjamin, R.C. Silveira, R.S. Procianoy   +2 more
doaj   +1 more source

Observed causes of severe respiratory distress among children with congenital heart disease

Nigerian Journal of Medicine, 2020
Background: Severe respiratory distress is a clinical feature commonly observed among children with congenital heart disease (CHD), but the underlying cause is often misdiagnosed. Objectives: This study is aimed at determining the common causes of severe
Chinawa Josephat Maduabuchi, D Uleanya Nwachinemere, O Onukwuli Vivian, T Chinawa Awoere, O Obidike Egbuna, F Chukwu Bartholomew   +5 more
doaj   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Respiratory Distress in Full Term Outborn Neonates: A Hospital Based Study

مجلة كلية الطب, 2013
Summary: Background: Respiratory distress remains a major problem post adaptation and one of the most common reasons for admission of neonates to Intensive Care. Objectives: To study the causes and short term outcomes of respiratory distress in full term
Manal B. Naoom, Ahmed A. Abdul-Zahra, Yasir A. Alsaadi   +2 more
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis

Critical Care, 2019
Background With the development of new techniques to easily obtain lower respiratory tract specimens, bronchoalveolar lavage fluid and other lung fluids are gaining importance in pulmonary disease diagnosis.
Yishan Wang, Huijuan Wang, Chunfang Zhang, Chao Zhang, Huqin Yang, Ruiyue Gao, Zhaohui Tong   +6 more
doaj   +1 more source

Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort study [PDF]

, 2021
Antonio Moreno, Raquel Carbonell, Ignacio Martín‐Loeches, Jordi Solé‐Violán, Eudald Correig, Josep Gómez, Manuel Ruíz-Botella, Sandra Trefler, María Bodi, Josefa Murcia Payá, Emili Dı́az, Pablo Vidal, Elisabeth Papiol, Antonio Moreno, Susana Sancho Chinesta, Lorenzo Socías Crespí, María del Carmen Lorente, Ana Loza Vázquez, R Vara Arlanzón, María Teresa Recio, Juan Ballesteros, Ricard Ferrer, Elisabeth Rey, Marcos I. Restrepo, Ángel Estella, Antonio Margarit Ribas, Neus Guasch, Luis Felipe Reyes, Judith Marín‐Corral, Alejandro Rodríguez, the COVID-19 SEMICYUC Working Group   +30 more
openalex   +1 more source

Artificial Intelligence‐Driven Soft Bioelectronics for Self‐Powered Respiration Monitoring

Advanced Science, EarlyView.
Artificial intelligence‐driven soft bioelectronics for self powered respiration monitoring based on triboelectric nanogenerators (TENGs), piezoelectric nanogenerators (PENGs), and magnetoelastic generators (MEGs) enable continuous and multi‐scenario respiratory biomechanical data collection. Coupled with machine learning and big data driven diagnostics,
Xinkai Xu, Xiao Xiao, Rui Guo, Jun Chen
wiley   +1 more source

Comparing the tissue Doppler-derived left ventricular myocardial performance index before and after recovery from respiratory distress in neonates: A prospective observational study

Annals of Pediatric Cardiology
Background and Objective: Respiratory distress is the most common cause requiring neonatal intensive care unit admission. As respiratory and cardiac functions are closely interrelated, some cardiac dysfunction is expected in respiratory distress.
Nikita Panigrahi, Harohalli A. Venkatesh, Manas Ranjan Mishra, Rajath Pejaver, Karthik N. Nagesh   +4 more
doaj   +1 more source