Results 41 to 50 of about 31,475 (257)

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga   +20 more
wiley   +1 more source

Transient respiratory distress syndrome in the newborn. [PDF]

open access: yesArchives of Disease in Childhood, 1967
The variable duration and severity of the respiratory distress syndrome (RDS) make it difficult to assess any therapeutic regime. We have observed 12 infants who at age 4 hours had clinical and biochemical findings indicative of moderate to severe respiratory distress syndrome but who improved rapidly with a standard therapeutic regime, their ...
J J, Downes   +3 more
openaire   +2 more sources

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar   +6 more
wiley   +1 more source

Familial Clustering of Unexplained Transient Respiratory Distress in 12 Newborns from Three Unrelated Families Suggests an Autosomal-Recessive Inheritance

open access: yesThe Scientific World Journal, 2007
We report on 12 near-term babies from three families in which an unexplained transient respiratory distress was observed. No known risk factor was present in any family and no sequelae were recorded at follow-up.
Andrea Guala   +9 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

open access: yesBMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang   +12 more
wiley   +1 more source

Alpha-2-macroglobulin levels in early respiratory distress syndrome

open access: yesThe Turkish Journal of Pediatrics, 1998
The vasoactive products of uncontrolled protease activity can play an important role in the pathogenesis of respiratory distress syndrome in newborn infants.
M Yurdakök   +4 more
doaj  

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

open access: yesEpilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze   +19 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

open access: yesEpilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus   +7 more
wiley   +1 more source

Preterm assisted vaginal births and associated maternal and neonatal outcomes: A retrospective study in a tertiary hospital

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives This study compares maternal and neonatal outcomes between preterm vacuum and forceps‐assisted vaginal births and evaluates preterm outcomes between those <34 + 0 weeks gestation to those ≥34 + 0. Methods This study is a single‐center retrospective cohort study of all singleton assisted vaginal births during 2014–2021. Delivery data
Caroline Leps   +7 more
wiley   +1 more source

Comparative evaluation of the effects of BLES and Survanta on treatment of respiratory distress syndrome in newborns

open access: yesJournal of Family Medicine and Primary Care, 2018
Background and Objectives: Symptoms of respiratory distress syndrome (RDS), which is inverse correlation with gestational age and birth weight, occur in premature infants and newborns.
Ali Aghayar Macooie   +2 more
doaj   +1 more source

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