Results 51 to 60 of about 484,803 (330)

A efetividade do decúbito ventral na Acute Respiratory Distress Syndrome: revisão sistemática

RIIS: Revista de Investigação & Inovação em Saúde, 2023
Enquadramento: o decúbito ventral é uma prática clínica baseada na evidência que se encontra bem estabelecida em pacientes com Acute Respiratory Distress Syndrome submetidos a ventilação mecânica invasiva.
Sílvia Marlene Barradas Ramos, Aramid José Fajardo Gomes, Ana Luisa Rego, Pedro Ezequiel Martins Pimenta, José António Pinho Silva, Silvana Peixoto Martins, Ana Catarina da Costa Maia, Ana Paula Macedo   +7 more
doaj   +1 more source

Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids

Critical Care Explorations, 2021
OBJECTIVES:. Unbiased global metabolomic profiling has not been used to identify distinct subclasses in patients with early sepsis and sepsis-associated acute respiratory distress syndrome.
Angela J. Rogers, MD, MPH, Aleksandra Leligdowicz, MD, PhD, Kévin Contrepois, PhD, Alejandra Jauregui, BSc, Kathryn Vessel, BSc, Thomas J. Deiss, BSc, Annika Belzer, BSc, Tom Liu, MD, Matthew Lippi, MD, MPH, Serena Ke, BSc, Erin Ross, BSc, Hanjing Zhou, MSc, Carolyn Hendrickson, MD, MAS, Antonio Gomez, MD, Pratik Sinha, MD, PhD, Kirsten N. Kangelaris, MD, Kathleen D. Liu, MD, PhD, Carolyn S. Calfee, MD, MAS, Michael A. Matthay, MD   +18 more
doaj   +1 more source

European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2019 Update

Neonatology, 2019
As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update of “European Guidelines for the Management of RDS” by a European panel of experienced neonatologists and
D. Sweet, V. Carnielli, G. Greisen, M. Hallman, E. Ozek, A. T. te Pas, R. Plavka, C. Roehr, O. Saugstad, U. Simeoni, C. Speer, M. Vento, G. Visser, H. Halliday   +13 more
semanticscholar   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Acute Respiratory Distress Syndrome

Jurnal Respirasi, 2018
Acute respiratory distress syndrome (ARDS) is a syndrome, a combination of clinical and physiological observations that describe a pathological state. The pathogenesis of ARDS is not completely clear and there is no gold standard for diagnosis.
Arief Bakhtiar, Rena Arusita Maranatha
doaj   +1 more source

Paediatrics: how to manage acute respiratory distress syndrome

Drugs in Context, 2021
Background: Acute respiratory distress syndrome (ARDS) is a significant cause of mortality and morbidity amongst critically ill children. The purpose of this narrative review is to provide an up-to-date review on the evaluation and management of ...
Kam Lun Hon, Karen Ka Yan Leung, Felix Oberender, Alexander KC Leung   +3 more
doaj   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome.

New England Journal of Medicine, 2020
BACKGROUND In patients with acute respiratory distress syndrome (ARDS), the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network recommends a target partial pressure of arterial oxygen (Pao2) between 55 and 80 mm Hg.
L. Barrot, P. Asfar, F. Mauny, H. Winiszewski, Florent Montini, J. Badie, J. Quenot, S. Pili-Floury, B. Bouhemad, G. Louis, B. Souweine, O. Collange, J. Pottecher, B. Levy, M. Puyraveau, L. Vettoretti, J. Constantin, G. Capellier   +17 more
semanticscholar   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source