Results 51 to 60 of about 263,067 (305)

A efetividade do decúbito ventral na Acute Respiratory Distress Syndrome: revisão sistemática

RIIS: Revista de Investigação & Inovação em Saúde, 2023
Enquadramento: o decúbito ventral é uma prática clínica baseada na evidência que se encontra bem estabelecida em pacientes com Acute Respiratory Distress Syndrome submetidos a ventilação mecânica invasiva.
Sílvia Marlene Barradas Ramos, Aramid José Fajardo Gomes, Ana Luisa Rego, Pedro Ezequiel Martins Pimenta, José António Pinho Silva, Silvana Peixoto Martins, Ana Catarina da Costa Maia, Ana Paula Macedo   +7 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids

Critical Care Explorations, 2021
OBJECTIVES:. Unbiased global metabolomic profiling has not been used to identify distinct subclasses in patients with early sepsis and sepsis-associated acute respiratory distress syndrome.
Angela J. Rogers, MD, MPH, Aleksandra Leligdowicz, MD, PhD, Kévin Contrepois, PhD, Alejandra Jauregui, BSc, Kathryn Vessel, BSc, Thomas J. Deiss, BSc, Annika Belzer, BSc, Tom Liu, MD, Matthew Lippi, MD, MPH, Serena Ke, BSc, Erin Ross, BSc, Hanjing Zhou, MSc, Carolyn Hendrickson, MD, MAS, Antonio Gomez, MD, Pratik Sinha, MD, PhD, Kirsten N. Kangelaris, MD, Kathleen D. Liu, MD, PhD, Carolyn S. Calfee, MD, MAS, Michael A. Matthay, MD   +18 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Acute Respiratory Distress Syndrome

Jurnal Respirasi, 2018
Acute respiratory distress syndrome (ARDS) is a syndrome, a combination of clinical and physiological observations that describe a pathological state. The pathogenesis of ARDS is not completely clear and there is no gold standard for diagnosis.
Arief Bakhtiar, Rena Arusita Maranatha
doaj   +1 more source

Recruitment manoeuvres in acute respiratory distress syndrome: Little evidence for routine use [PDF]

, 2013
Acutely injured lungs consist of heterogeneous regions of aerated and collapsed alveoli. Implementation of alveolar recruitment manoeuvres (RMs) for the management hypoxemic respiratory failure, however, has been controversial.
Oliver Poole
core  

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Prone position in acute respiratory distress syndrome

, 2002
In the last few years prone positioning has been used increasingly in the treatment of patients with acute respiratory distress syndrome (ARDS) and this manoeuvre is now considered a simple and safe method to improve oxygenation.
PELOSI, PAOLO PASQUALINO, BRAZZI L, L. Brazzi, P. Pelosi, GATTINONI L., Brazzi, Luca, L. Gattinoni   +6 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source