Results 211 to 220 of about 955,664 (289)

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Adverse Event Reporting Patterns Associated with Concomitant Use of 5-HT3 and NK-1 Receptor Antagonists: A Large-Scale Spontaneous-Reporting Analysis. [PDF]

Pharmaceuticals (Basel)
Zhao R, Tang S, Han M, Hu H, Guo J, Lv M, Sun J, Zhou X.   +7 more
europepmc   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, Volume 117, Issue 6, Page 1485-1499, December 2026.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Comparison of Peripherally Inserted Central Catheters versus Central Venous Catheters in a Medical Intensive Care Unit: A Single-Center Retrospective Study. [PDF]

Int J Gen Med
Long G, Jia C, Peng H, Li Y.
europepmc   +1 more source

Clopidogrel-Induced Hypersensitivity Syndrome Presenting as a Progressive Rash: A Case Report. [PDF]

Cureus
Saghari S, Geha M, Arbabi M, Babary H.
europepmc   +1 more source

Revealing the Key Genetic Basis of Late Leaf Spot Resistance in Peanut by Combining QTL Mapping, QTL‐seq and RNA‐seq

Plant, Cell &Environment, Volume 49, Issue 12, Page 10442-10455, December 2026.
ABSTRACT Late leaf spot (LLS) is the most widespread and destructive fungal disease affecting peanut worldwide, yet relatively little is known about its genetic basis. In this study, QTL mapping using a 1327‐bin map (derived from 9533 SNP/InDel markers) and multi‐environment phenotypic data repeatedly detected two major LLS‐resistance QTLs on ...
Wenhui Cui, Pengxia Guo, Bolun Yu, Huifang Jiang, Yong Lei, Boshou Liao, Huaiyong Luo, Xin Wang, Li Huang, Nian Liu, Jianbing Guo, Weigang Chen, Xiaojing Zhou   +12 more
wiley   +1 more source

Vanilla and Vanillin as Probable Causes of Hypersensitivity Reactions and Vaping Cytotoxicity. [PDF]

Curr Issues Mol Biol
Lis K.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, Volume 20, Issue 11, Page 2584-2610, November 2026.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Rate-controlled intravenous voriconazole rapid desensitization in a patient with chronic pulmonary aspergillosis and triazole hypersensitivity. [PDF]

IDCases
Yasue E, Ogawa T, Mano Y, Takeuchi T, Harada K, Kimizuka Y.   +5 more
europepmc   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2246-2260, November 2026.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source