Results 191 to 200 of about 1,287,362 (306)

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Enterovirus-D68-Neglected Pathogen in Acute Respiratory Infections: Insights from Croatia. [PDF]

Pathogens
Hruskar Z, Skara Abramovic L, Ferencak I, Juric D, Lozic J, Juric A, Bocka B, Bajek M, Josipovic M, Bekic V, Tabain I.   +10 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Rapid emergence of transmissible SARS-CoV-2 variants in mild community cases

Microbiology Spectrum
Michael A. Crone, Seran Hakki, Joe Fenn, Jie Zhou, Carolina Rosadas de Oliveira, Kieran J. Madon, Aleksandra Koycheva, Anjna Badhan, Jakob Jonnerby, Sean Nevin, Emily Conibear, Romain Derelle, Robert Varro, Constanta Luca, Shazaad Ahmad, Maria Zambon, Wendy S. Barclay, Jake Dunning, Paul S. Freemont, Graham P. Taylor, Ajit Lalvani   +20 more
doaj   +1 more source

Vaccination Against Respiratory Infections in Adults with Cancer: A Concise Guide for Clinicians. [PDF]

Vaccines (Basel)
See KC.
europepmc   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

The mediating role of acute respiratory infections in temperature-mortality associations in the Czech Republic, 1982-2019. [PDF]

Int J Biometeorol
Borisova E, Ballester J, Hanzlíková H, Plavcová E, Kyselý J, Kynčl J, Urban A.   +6 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Immune dysregulation triggered by inflammatory cytokines in patients with severe respiratory infections. [PDF]

Respir Res
Li J, Liang S, Li Y, Wu J, Li C, Gan J, Li W, Wang C.   +7 more
europepmc   +1 more source