Results 151 to 160 of about 197,942 (309)

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Renal Insufficiency in Terminal Respiratory Failure [PDF]

, 1958
D. A. K. Black, Sarah Stanbury
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Pancreas Cancer-Associated Weight Loss. [PDF]

, 2019
Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S, Hendifar, Andrew E, Matrisian, Lynn M, Petzel, Maria QB, Picozzi, Vincent J, Precision Promise Consortium, Rahib, Lola, Zimmers, Teresa A   +7 more
core  

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Inflammatory Response as a Mechanism of Perinatal Programming: Long-term Impact on Pulmonary and Renal Function? [PDF]

, 2012
RATIONALE: Temporal changes in the fetal environment, such as malnutrition and placental insufficiency induce intrauterine growth restriction (IUGR) and lead to a permanent changes of physiological processes later in life.
Alejandre Alcázar, Miguel Angel
core  

Gastroplasty for Respiratory Insufficiency of Obesity

, 1981
Harvey J. Sugerman, R. Paul Fairman, Alice K. Lindeman, James A.L. Mathers, Lazar J. Greenfield   +4 more
openalex   +2 more sources

A Shape‐Adaptive, Performance‐Programmable, Self‐Healable and On‐Demand Destructible Robotic Skin via Self‐Strengthening Dynamic Silicone

Advanced Science, EarlyView.
Enabled by the distinctive inter‐ and intra‐chain siloxane exchange in commercially available silicones as the dielectric layer, the omni‐adaptive robotic skin (OmniAdapt) integrates multiple advanced functionalities: programmable sensing performance via the self‐stiffening dielectric material, application as BPM sensor, shape adaptivity for electronic
Wusha Miao, Lara S. Laamari, Jing Yu, Sanjay Schreiber, Lukas Heer, Jiacheng Cui, Jiayuan Huang, Hedan Bai   +7 more
wiley   +1 more source

Unmasking MEGF10 Myopathy: A Rare Cause of Sudden Respiratory Failure in a Young Adult

Case Reports in Neurological Medicine
Sudden respiratory insufficiency is commonly attributed to cardiopulmonary causes but may also herald underlying neuromuscular disorders. In this context, rare diseases in particular pose significant diagnostic challenges.
Benedict Kleiser, Luise Hackenbruch, Jens Schittenhelm, Antje Bornemann, Tobias Haack, Alexander Grimm, Pascal Martin   +6 more
doaj   +1 more source

Respiratory insufficiency. Advances in diagnosis and treatment. 2. Treatment. 2. Physical therapy for respiratory insufficiency.

, 1990
吉田 稔, 瀧原 宏憲
openalex   +2 more sources